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MASS SPECTROMETERS

Agilent 6560 ESI-IMS-Q-TOF

High-resolution drift tube ion mobility spectrometry, electrospray ionization, Q-TOF. Mainly used to study nucleic acid G-quadruplex and riboswitch folding in solution and in the gas phase in soft conditions and for structural investigation on supramolecular complexes. The drift tube is operated in Helium or Nitrogen. The pumping system is modified to allow accurate measurement in helium.

 

Bruker timsTOF SCP

High-resolution dual-tims ion mobility spectrometry, electrospray ionization, Q-TOF.

Optimized for non-covalent complexes.

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Bruker timsTOF Omni

High-resolution dual-tims ion mobility spectrometry, electrospray ionization, Q-TOF coupled with omnitrap.

Optimized for non-covalent complexes and Nucleic acids TopDown sequencing.

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Modified Bruker Amazon ESI-IMS-Trap

Electrospray ionization, 3D ion trap modified and coupled to a tunable OPO laser (195 to 2000 nm) (GWU, premiscan with ultra low divergence (ULD). The pump laser is a spectra-physics Quanta-ray pro 230-30.

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The instrument is used to study nucleic acid  folding in solution and in the gas phase in soft conditions (ERC project).

Top-down analysis (UVPD) are performed on non-covalent complexes.

A high-resolution drift tube operated in Helium is coupled to the instrument. IMS-IMS-MS experiments can be performed.

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We developped Mass-resolved electronic circular dichroism ion spectroscopy (Science, 2020, 368, 1465)

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Continuum Powerlite and Panther EXplus OPO

High power nanosecond tunable pulsed laser from 215 to 2000 nm. It is used to performed UVPD.

 

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Temperature-controlled nanoelectrospray source  (J. Am. Chem. Soc. 2018,  140, 12553-12565).

Copper block

T° range: 3 - 95°C

Volume of solution: 3-10 µL

Typical experiments: from 20 to 85°C in 40 min

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