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Our group is developing mass spectrometry methods. A mass spectrometer is an instrument that measures the masses of each molecule in a sample. We also want to know how and why molecules interact with one another. In particular, we are interested in how pieces of DNA or RNA interact with ions (sodium, potassium,…) or with other molecules.

The mass spectrometer tells us which molecules become partners, because when they form a complex, their masses add up. We also develop other techniques called ion mobility spectrometry and ion spectroscopy to determine the three-dimensional arrangement of the nucleic acid complexes—which mass alone cannot tell—and how the structure and interactions depend on temperature or energy.

NEWS:

The Gabelica group is opening a new laboratory at the University of Geneva and is hiring several PhD candidates and 1 post-doc in bioanalytical, biopharmaceutical and biophysical mass spectrometry with special focus on nucleic acids

                     PhD and postdoc positions MS in Geneva

See our Tutorial on Mass spectrometry to study G-quadruplex biophysics (by Valérie Gabelica): youtube

Valérie Gabelica received the inserm Research Price for the study of the conformation and interaction of molecule using Mass Spectrometry

Valerie Gabelica received Heinrich Emanuel Merck Award for Analytical Science for her outstanding work on advancing mass spectrometry to study nucleic acid structures and interactions.

 

Valerie Gabelica received the LILIANE BETTENCOURT PRIZE FOR LIFE SCIENCES.

 

              see also       Coverage in YOUTUBE

                                   coverage in SudOuest and FR3 TV

                                   interview for the University Newsletter

Check out our latest article in Science: "Mass-resolved electronic circular dichroism ion spectroscopy"

              see also       perspective by Perdita Barran

                                   coverage in Chemical & Engineering News

                                   interview for the University Newsletter

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