Our group is developing mass spectrometry methods. A mass spectrometer is an instrument that measures the masses of each molecule in a sample. We also want to know how and why molecules interact with one another. In particular, we are interested in how pieces of DNA or RNA interact with ions (sodium, potassium,…) or with other molecules.
The mass spectrometer tells us which molecules become partners, because when they form a complex, their masses add up. We also develop other techniques called ion mobility spectrometry and ion spectroscopy to determine the three-dimensional arrangement of the nucleic acid complexes—which mass alone cannot tell—and how the structure and interactions depend on temperature or energy.
NEWS: Check out our latest article in Science: "Mass-resolved electronic circular dichroism ion spectroscopy"
see also perspective by Perdita Barran
coverage in Chemical & Engineering News
interview for the University Newsletter